Saturday, August 31, 2019
Manga vs American Comics
In the world today, due to the ease of distribution and commerce, we see much diversity of products all over the place. A high competitors in this are comics, the American comic battling the Japanese comic (manga). There is a big difference in art styles between Manga, which is more exaggerated and American comics, which tend to be more ââ¬Å"realisticâ⬠. There are also quite a few serious differences between the two types of comics. Some of the differences, just to mention a few of them are the cost, creation, diverse audience and genres, presentation and even size. Many continue reading the American comics because it is traditional, eye catching, and they like heroes. However more are turning to manga instead for it appeals to their everyday lifestyles, itââ¬â¢s simple, and there is a lot more content. Manga will be more prominent than American comics without a doubt. The creation of Manga and its layout is quite different than American Comics. Manga is printed in black and white format while American comics are for the most part in full color. Also, when you look at a graphic novel or Manga you will notice there is a great difference in the size. Manga is frequently smaller than traditional American comic books, usually digest-size and roughly half or less the size of American comics. Where the American comics are generally thin like a small magazine, Manga is thick and with many more pages. This not only makes it more comfortable for the reader it also provides more content keeping their attention longer. In page count, Manga is quite similar to graphic novels, which are often just collections of the ongoing American comics. But unlike American graphic novels, which are usually just a collection of monthly comics in a single unified story or story arc, Manga books are often apart of an even bigger story and a complete Manga storyline can run thousands of pages. Another difference between traditional American comics is that mainstream American comics are often created in a sort of assembly-line fashion. They have a writer, a penciler (initial sketch), inker (uses a pen to ink over the sketch), letterer (adds dialog) and a colorist. Most Manga books are done by a single creator, who combines all those chores except coloring. Also Manga story lines usually move at a much quicker pace. Due to the high page count, one reads a Manga book at an accelerated pace. Manga books almost always have fewer panels and less dialogue (rambling) per page than American comic books. Check the average Japanese comic book, and youââ¬â¢ll find lots of wordless art. Some of this may be establishing shots, setting a scene or a mood. Some of it may be pure visual action or suspense, told solely through motion, facial expressions, or body language. The price for Manga is also less than the average comic book and a bit less than a standard paperback novel, the small size of Manga and black-and-white printing rather than full color keeps the cost down. The lack color is made up when you consider the story development that it'll have with the amount of pages it has. In Japan, Manga is not viewed as just for kids unlike the American stereotype. There pretty much is a Manga for everyone. With that being stated there are three main genres in Japanese Manga: Shonen Manga (boy's comics), Shojo Manga (girl's comics) and Hentai (adult comics). Shonen Manga is pretty much comics that are primarily action and/or adventure geared. Shojo Manga is for the opposite sex; they are often about relationships and/or love interests. Please note that even though a particular genre is geared towards a certain audience it's not limited to just that audience (unless otherwise stated). Hentai Manga are more focused on the sexual aspect of adulthood usually banned from those younger than the limit. While American comics tend to fall into a few specific genres (superhero, science fiction, etc. ), Japanese comics are designed for a much wider range of reading interests. There are Japanese comics for young boys and girls to adults of all tastes and interests. There are sports comics, soap-opera comics, ambitious business comics ââ¬â just about any topic you can name. Many of these are much too specialized for the American market, but they are fascinating to know about. With this look at the competing markets, I believe that Manga will just take over due to its large variety. American comics having been based of history or such figures have a harder time keeping up. Manga arenââ¬â¢t as reliant on a base and a set of rules which allows them to adapt or simply tell whatever the story is. Until American comics can find that flexibility they simply wonââ¬â¢t be able to keep up with Manga.
Friday, August 30, 2019
Catal Huyuk Women Essay
The general topic is about the role of women in this early agricultural society. Catal Huyuk had a population of 8,000 people and only 2,000 houses. Also, there werenââ¬â¢t any streets so they had to walk along the roofs and enter their homes through their roofs. Their homes were decorated with sculptures and paintings to illustrate animals and human figurines. The authorââ¬â¢s basic point is to explore the findings and tell from them the type of society Catal Huyuk was and the roles of both men and women. Of course there could be evidence of both matriarchies and patriarchies but finding out what were the main roles of both sexes. In todayââ¬â¢s world we see more of a patriarchy due to men having more complex and dangerous jobs and when women do have the same job their pay isnââ¬â¢t equal to the men pay. Information such as women figurines was found. During the first excavations in the early 1960ââ¬â¢s, a figurine was discovered. The sculpture was a heavyset woman sitting on a seat with an animal on each side that could possibly be leopards. It is said that the women could have worshiped a powerful mother goddess and it is likely that the figurine can be just that. It seemed that it was mostly, or started off as, a patriarchy. Ian Hodder states ââ¬Å"cultural anthropology provides no substantiated claims for true matriarchiesâ⬠(Hodder pg 78). The article has both strengths and weaknesses in my point of view. The strength of this article is the total information about Catal Huyuk and explanations of why there isnââ¬â¢t much evidence. The weakness of this article is that it gives more information about the settlement and not the evidence of roles. I believe that this article has been a bit limp due to the lack of evidence showing the roles of men and women. Though there wasnââ¬â¢t much differentiation of roles that could show that social roles werenââ¬â¢t important. The strongest evidence found was the diet of men and women from this settlement. The only evidence found in teeth was that women had more cavities than men but both had similar diets and lifestyles. Also, women did the cooking and men did the stone making. In addition, many births were taking place and many bodies were found of women who were pregnant that might show that women made more sacrifices. Iââ¬â¢ve learned that finding out roles of men and women could be difficult depending on bones. But there could have been little evidence due to the unimportance of roles as previously mentioned. If our world showed no care to social roles, a lot of things would be different. Job preferences would definitely different. In some countries social roles arenââ¬â¢t important and therefore, they have less social and maybe economical problems than we do here. To follow up on the research presented I would search for more recent information and information from earlier research. Because only 18% of the site was excavated, more and more excavations could be done and more new information could be discovered.
Thursday, August 29, 2019
Veni Vidi Vici Vimy (Vimy Ridge for Canada)
Veni, Vidi, Vici Vimy (following the outline plan given in 3. 10) Introduction Paragraph: ââ¬â World War 1, defining moment for Canadian nationalism. Did not escape unscathed, but the participation in the war gave a stronger sense of nationhood. ââ¬â Canada's contributions into WWI led to international recognition; other countries must recognize you as sovereign. ââ¬â The effort also brought acknowledgement to Canada's contributions and heroism on the battlefields of Europe, giving Canada the shot to be a more-mature, experienced nation because of the sacrifices made by their armed forces. The Battle at Vimy Ridge was the greatest assertion in Canadian sovereignty in WWI. Body Paragraph 1: ââ¬â Canada stepped up to the plate because of their ties to Britain; originally, wanted nothing to do with the World War, but a sense of duty and owing Britain their help through the war persuaded them otherwise. ââ¬â Alliances and history tied many countries together. If one g ot pulled into the war, others did too. Something like a chain-reaction. Canada did not have much reason to fight, other than Britain called for the aid they had promised earlier; Canada thought they might escape untouched by the war, but they lost many citizens, materials, family, loved ones and experienced the financial loss that war brings. Canada also had to bear knowing many of their people were overseas, far from home, fighting for someone else's war. ââ¬â Fought and participated in many battles, with one of the most prominent being their victory at Vimy Ridge. Body Paragraph 2: ââ¬â From July to mid-November 1916, the Battle of the Somme claimed 24,029 Canadian casualties.Greater loss than expected. It also gave Canadian units the reputation of a formidable assault force. ââ¬â Canadians' first taste of the Battle of the Somme occurred when they were asked to secure the town of Courcelette, France. November 11, the Canadian Division finally secured most of the Germ an trenches in Courcelette and then rejoined the Canadian Corps at Vimy Ridge. ââ¬â Prime Minister Lloyd George: ââ¬Å"The Canadians played a part of such distinction that thenceforward they were marked out as shock troops; for the remainder of the war they were brought along to head the assault in one great battle after another.Whenever the Germans found the Canadian Corps coming into the line they prepared for the worst. â⬠Body Paragraph 3: ââ¬â April 12, Hill 145 fell, Vimy Ridge was won over by Canadian troops. The whole plan was entirely devised by Canada and was independent of British thoughts. ââ¬â The success in the capture of the ridge earned Canada a reputation of great strength and accomplishment, and it was also the first time that Canada had ever planned its own attack without British help. It was the first step towards Canada's independence and sovereignty. Even under British rule, Canadian troops planned, rehearsed, followed through, and defeated th e Germans at Vimy Ridge under the command of Canadian officers and officials. ââ¬â Although the victory came with a great cost, with more than 10,000 killed and wounded, it helped prove Canada in front of other world countries. Concluding Paragraph: ââ¬â I believe that the effort put into it by Canada gave the world a chance to recognize Canada's contributions and heroism after the battles they fought and won on the European battlefields. Canada was given the chance to be perceived as a mature, wiser nation through the sacrifices it made during the war. ââ¬â The Battle at Vimy ridge was the exceptional proclamation of Canadian sovereignty in WWI. ââ¬â World War 1 was an interpreting moment for Canadian nationalism in many ways and instances. Although Canada didn't make it through the war untouched or without dissension, our role in the war gave us a greater and stronger sense of nationhood.
Answer Job Interview Questions Assignment Example | Topics and Well Written Essays - 500 words
Answer Job Interview Questions - Assignment Example During vacations, I have been able to work in the marketing department of Toyota Company and where I gathered tangible experience about marketing. The talent of communication and negotiation that I possess is a key component in marketing as it will help one to gauge the ability to buy as well as the behavior patterns of the customer. I am highly motivated and work best under no strict supervision. A team player and a positive result oriented person. My strengths are that I am highly motivated and positive and focused result oriented person with the abilities of teamwork and good interpersonal communication skills. During my internship at the Toyota Company, these skills enabled me to move sales worth $ 1 million in three weeks. As such I am capable of delivering in the sector of business for a firm as a whole. My weakness is that my failures in anything I do make me fill demoralized and weak. However, I have been putting a concerted effort to take my failures as lessons and learn from them. I am applying for a job with this company because it is one of the best .marketing companies in the country with a strong brand name in marketing. By working here, I will be put my expertise to use and also learn more about my career as marketing officer. This will give the opportunity to be part of the great reputation that the company posits to the outside world. As a marketing intern with the Toyota Company, a valuable customer came to inquire about the issue of breaking system with his car. This was following the withdrawal of thousands of cars all over the world over the same issue; I was able to explain to him the reasons for the withdrawal of the vehicle and the duration it was to take as well as the need for doing so to his satisfaction. The incident when I was given what seemingly was an achievable target to sell up to 6 high valued cars within a month. It seemed hard, but I managed through teamwork and aggressive networking that made me sell up
Wednesday, August 28, 2019
The Golden Proportion Essay Example | Topics and Well Written Essays - 2250 words
The Golden Proportion - Essay Example Most commonly, golden triangles and golden rectangles are used. A shape qualifies as ââ¬Å"goldenâ⬠when the ratio of longest side to shortest side equals 1.61803399â⬠¦ Regular pentagons and pentagrams are also closely associated with the Golden Ratio. When a regular pentagon is constructed and the interior angles are connected with straight lines, the result is a series of triangles, each one of them golden, that form the image of a pentagram. This symbol, a pentagram transcribed by a regular pentagon became significant to the Pythagoreans. This group of people, led by the Greek mathematician Pythagoras played an important role in the early history of the Golden Ratio. Throughout history, the Golden Ratio has been known by many different names. It has been called the golden section, golden mean, symbolized by the Greek letter phi (à ¦), the divine proportion, and the mean of Phidias. Some of these names solidly link the origins of the Golden Ratio with the ancient Greeks. In ancient Greece, many famous mathematicians and artists are associated with the use and development of our current understanding of the Golden Ratio. These groundbreaking individuals were interested in the Golden Ratio for different reasons. Some were intrigued simply by the unique mathematical properties of this peculiar ratio, while others sought to utilize the aesthetic strengths of the ratio when developing their art and architecture. A notable mathematician and mystic that had great influence on the discovery and utilization of the Golden Ratio was Pythagoras. The personal history of Pythagoras is colorful and full of legends. None of his actual writings have survived, so it is impossible to tell which mathematical concepts he personally discovered. Pythagoras is most famous for the discovery of the Pythagorean Theorem. Pythagoras (or one of his followers) discovered that the square of the
Tuesday, August 27, 2019
Business Mission Term Paper Example | Topics and Well Written Essays - 500 words
Business Mission - Term Paper Example so because it has proved that information and technology not only results in business establishments realizing higher profits but it also makes work easier for workers thus reducing ion operational cost greatly. Despite there being a need for provision of information and technology solutions, cost has become a de-motivating factor that results in many companyââ¬â¢s especially small sized ones to opt not to seek the services of information and technology solution companies. This is so since normally the cost of both implementation and maintaining of information and technology infrastructure is usually high making no sense since it does not reduce the cost of operation. Therefore, the companyââ¬â¢s primary goal is to provide affordable information and technology solutions to companies of any size at reasonable costs. This will be through taking advantage of advancement in technology that has resulted in the reduction of the implementation of information and technology solutions. For example, Total Solutions will optimise the use of cloud computing which will be instrumental in significantly reducing the cost of implementation since business establishment will not be required to purchase unnecessary hardware such as servers. The company will be backing up respective clients data remotely through cloud computing. The companyââ¬â¢s stakeholders are private investors who were gotten as the business idea was pitched to them. The government is also a silent stakeholder in the fact that it has not invested in the company. However, it has provided the company with a soft loan since it realized the importance of providing information and technology so lutions at affordable cost. Thus, the mission statement for the company is providing affordable and quality total solutions for business establishment. In the short-range the corporation is expected to be among the top 100 midsized companies in the country. This is in tandem with its strategic plan where it will start off by
Monday, August 26, 2019
REPORT Essay Example | Topics and Well Written Essays - 2000 words
REPORT - Essay Example Staff at the restaurant should address customers politely avoiding stereotypes along race or class. The FAMM model The Five Aspects Meal Model refers factors that play an important role in the restaurant to make the meal experience an entire process. These factors include the room, the meeting, the product, the management control system and the atmosphere. The meeting Service and service quality is considered as a ââ¬Ëmeetingââ¬â¢ depending on the way that the customer is treated. To understand the value of the meeting, a restaurant staff needs to have knowledge of social psychology and rules of etiquette. Higher education is vital for service staff to exhibit mature social interaction in the restaurant. Service staffs make the major contact between a client and the restaurant. A waiter should to explain to the client what is in the menu and the preparation time of meals in a friendly manner. Arrogant waiters can make the whole dining experience very boring to the client. Waite rs should also understand that customers might elevate their own social status in a restaurant. A customer can pretend to be successful and rich. (Kivela, 1994, pp 24).Waiters should be able to assist customers who are less experienced in hotel dining. A waiter who is more helpful than arrogant to an ignorant client will help the restaurant obtain a good reputation.(Finkelstein,1989, pp 34). The room Many meals are consumed in a room. The person offering meals in a commercial setting should improve the eating environment to meet the clientââ¬â¢s needs in the best way. Decoration of the room should take into consideration aspects such as style, history of the room, and the design of the room. The created eating environment in a restaurant setting is called a ââ¬Ëservice scapeââ¬â¢ (Bitner, 1992, pp102). Modification of the context of a room can influence our taste of wine (Hersleth et al., 2003, pp54). The beliefs and past experiences of a client while consuming food in the same environment changes depending on the context of the eating. Meals need to be in agreement with the overall style of the restaurant (Bowen &Morris, 1995, pp56).Restaurant interiors should also be in agreement with the type of food offered. The product The product component is made of the foods and beverages served in a restaurant including their combination. Waiters in a restaurant are able to use their theoretical and practical knowledge of food and drink to suggest on choice of wine and food. The main purpose of having immense knowledge of food and beverages by the customer is to be able to satisfy the clientââ¬â¢s need for the perfect combination of food and beverages. A study by (Nygren, 2004, pp98) has shown that sometimes food and wine combinations fit together but occasionally they do not .The visual effect of the product also has an effect on the restaurant experience of the customer. A study by (Warde and Martens,2000pp210) shows that visual effect played a vital rol e in creating success for the restaurant. In some extreme cases, the appearance of the dish was an indicator of whether the restaurant had succeeded. The taste of the food should meet the expectation of the client.( Fine, 1992,pp104).Consumers of readymade food for example expect their food to taste good .Sensory characteristics of food is vital in any restaurant. The management control system. Leadership and economic issues are under the
Sunday, August 25, 2019
Photographs of the Lillis. Basic Elements of Photography and Essay
Photographs of the Lillis. Basic Elements of Photography and Representation versus Reality - Essay Example Even the elevators, which often, in school buildings, are run down, this was not the case in this building. The elevator, too, looked modern ââ¬â it was chrome, and like the rest of the building, was clean. That was probably the word that I would most use to describe this experience and the space - it was clean and uncluttered. I also liked the open-air feeling of the atrium, and the large windows gave the degree of natural light that was very relaxing for this experience. I can see why this would be a popular place for students, because the entire space gives an air of some place where people can relax, socialize and study. And this was the theme that was presented in this building ââ¬â it is obvious that the architects of this space had a relaxing and clean aesthetic in mind. There was nothing about this building that was industrial or garish or harsh. The walls were not painted in bright or dark colors, and there was very little wood that was exposed, either. No real indus trial look, like exposed pipes or something like that. From the tiled floors to the large meeting rooms, to the large atrium meeting hall, that was the aesthetic that was felt in this space. This was what so appealing about this space. As for what was unappealing about the space, I felt that perhaps the hallways, which were captured as part of these photographic sequences, seemed a little claustrophobic. They could have been widened a little to give even more of an impression of detail and relaxation. My photographing of this space was both intuitive and rational. That is, I gravitated towards certain parts of the building, just naturally ââ¬â this was something that I used to determine which photographs to take, which was the places where I felt most comfortable and relaxed. That said, there also was a rational approach to the picture taking. The rational approach was that I knew that I had to diversify in taking the pictures ââ¬â I couldnââ¬â¢t just take shots of the be auty of the building, without also taking shots of the mundane. Therefore, I felt the need to make sure that things like the chrome elevators were featured in this spread, as well as other things such as metal boxes and drinking fountains and other things that are important to a building, but may not be the main draw. I felt, consciously, that I needed to completely represent the building, as opposed to highlighting the high points. I did feel that the digital camera would give me a slightly different result than a traditional camera. That is because I would be able to see, in real time, how the photographs looked, and this is what I based my portfolio on. The real time photographs. I was able to note that I was hitting the points that I wanted to hit. If I was taking pictures with a traditional camera, this would not be available as much. I chose two photographs. The one photograph that I chose was the one of the students in their tables, with the open air windows in the background . The other photograph that I chose was the photograph of the metal boxes that were lined against one wall. The reason why I chose these two photographs, in particular, was that these represented opposite ends of the spectrum, in terms of aesthetics. I felt that, by choosing these two photographs, I represented the building the best. In other words, the building was not just about the beauty, but also about the mundane things that makes a building what it is. I felt that this was the best use of my photographerââ¬â¢
Saturday, August 24, 2019
Feminism - A Personal Perspective Essay Example | Topics and Well Written Essays - 1750 words
Feminism - A Personal Perspective - Essay Example Women often cannot and many a time are not allowed to transcend this idea that brings in its wake a burden of expectations and constraints. There exist definite and stereotypical ideas about what womanhood means and feminism is the field of study that intends to shatter such obnoxious and repressive ideas. Though womenââ¬â¢s study intends to place women at the center of all intellectual inquiries, the thing to be kept in mind is that the fact that feminism defies all stereotypical notions transcends all gender specifications. The fact that feminism intends to liberate women from the shackles of all preconceived notions also assumes the relevance of same rights and prerogatives for men. Feminism intends to revolt against all forms of repression of women and the rights it intends to seek are or should be universal, transcending all gender specifications. Feminists should remember that this ideal is not a philosophical pie in the sky but is, in fact, imperative for the relevance and sustenance of all forms of feminist struggles. ââ¬Å"The true form of revolutionary change is never merely the repressive situations that we seek to escape, but the piece of the oppressor that is planted deep within each of us.â⬠It is imperative for the adherents of feminism to not to fall into the male trap of hating men. The very fact of doing so not only justifies and establishes the stereotypical notions of masculinity in our society but at the same time authenticates the stereotypical notions about women.
Friday, August 23, 2019
Case Study Healthcare Funding Policies Term Paper
Case Study Healthcare Funding Policies - Term Paper Example 5 Works Cited 9 Name of the Student Name of the Professor Name of the Course Date Healthcare Funding Policies INTRODUCTION: HEALTH CARE POLICIES Presently, the costs of healthcare policies, intricacies in healthcare systems, cost challenges, and various other factors are responsible for the increase in the demand of the health care policies. Health decision making is vital to the growing economy as it ensures the welfare of the people and also has a profound impact on the socioeconomic, political, and cultural context. The different funding methods have different impact on the public health decision making and its way of choosing the regulatory mechanisms. The health care systems of varied nations are largely influenced by the guidelines prepared by World Health Organization (WHO). Similarly, the health care systems in the USA encompass various regulations that are enacted by the US government like Health Care and Education Reconciliation Act of 2010 and Patient Protection and Afford able Care Act. The US government plans to impose further regulations for the benefits of the common people. Health care policies of the USA will be introduced in the study and its benefits to the common people. ... HEALTH CARE POLICIES: UNIVERSAL HEALTH CARE POLICIES The growing health concerns among the common people, regarding the health care system in varied nations have led to frustration. Situations like overcrowded emergency rooms, extra fees for health care facilities and non government aid for health benefits are also regarded as important health issues (Jackson). Apart from health care policies, which are largely influenced by the government regulations, the health care policy consensus group is a collaboration of organizations, which signify various points on the continuum and the spectrum (ââ¬Å"How US health care reform will affect employee benefitsâ⬠).The key features of the universal health care policies are price consciousness, consumer empowerment, social solidarity, quality of healthcare, clinical autonomy, responsiveness, conflicts of interest etc. In the United Kingdom the health care facilities provided by the government are largely based on need and not the ability to pay. The National Health Services (NHS) provided by the government are free and provide medical facilities worth ?2400 annually. The UK health care policies are designed to keep in the mind the age, sex, education, race, and class of the common people. The social and health care insurance is designed by the government keeping universality, price regulation, open enrolment, and a regular benefits package system. Universality includes compulsory insurance, which includes subsidization for the sick and healthy patients. Price regulation includes risk compensation for the insurers especially for the highly risk ensured (Singh & Kant 200). In the USA the health mechanism is given due consideration and is not regarded as a gift,
Thursday, August 22, 2019
The media institutions operate under advance capitalism Essay Example for Free
The media institutions operate under advance capitalism Essay Today, just a handful of firms are responsible for most of the information that people sees, hears or reads. Most disturbing of the concentration of ownership is the unregulated and near-complete control over information in the hands of a small number of very powerful corporations. These big corporations of mass communication and media are becoming more and more influential our lives. The media institutions operate under advance capitalism. The information that we get is selected and framed to serve particular political and economic interests, such as commercial needs and corporate needs, but not individuals interests. The effect of TV, dairy newspaper, magazines and internet so far has largely been to increase the political crises and profit motive. If communication and media are abused, they can be used against society, and changing our world in a very negative way. Western democracies have free-market economies, in which individuals are at liberty to produce and consume according to their own interests.1 In our society, our democracy is based on the free exchange of information, on an open market place of ideas. Many communication activities have been returned to private hands from the public ownership due to the privatization and deregulation. There are several reasons for the concentration of ownership and the cut down of government regulation. Firstly, revenue-strapped governments have become eager to assign more and more areas of the economy to market forces.2 Some government action can lead to a less efficient allocation of resources and slow down the development of the economy. For example, regulatory agencies fixed the prices can only allow the corporate to earn a normal rate of return. In addition, due to the changing of economy, many small firms expand their power by selling to local market, merge up by a bigger corporation. The powerful corporation can fix the prices and control output to maximize the profits, which can benefit the economy growth. They can even cut prices to drive the other competitors out of the business. Implementing the intercept requirements could harm the competitiveness of our country products in the global market. Secondly, the growth of the technology allowed the market to expand without bound. For example, the Internet is a new method of communication and a source of information that is becoming more popular, which everyone can access it from anywhere and anytime. The government cannot interfere with what we see and hear makes it more and more difficult for national governments to assume control of cultural production. Thirdly, peoples sense of belonging to the national community has changed.3 People do not want to put more power in the hands of the government. They think government involvement creates even more problem than they can solve. Sometime can lead to a less efficiently, wasting time and money. The deregulations of the mass communication and media have threatened the public interests. The factors of concentration of ownership, the profit motive and advertisers interests are the main key to determining the production and the content of news and media. The press and the media are responsible for reporting news, issues and events as clearly as possible. Since we are educated about what is happening in the world around us and updated on issues that we care. Any distortions can cause the information to be misinterpreted or completely wrong, result in the misinforming of the public. However, based on the capitalism, large media corporations make profit by selling the audiences to the advertisers. For example, the economic structure of a newspaper is that it sells readers to other business. They are not really trying to sell newspaper to people. They just try to increase their readerships in order to increase the advertising rate.4 They are not trying to provide what people want to see, but to communicate the public to a large number of companies or businesses. The media content is depending on the advertising company, which can affect both the content of news as well as the process by which news is created. We have to think deeply about the questions such as: How all these factors affect peoples lives? What purpose does peoples lives serve as? Can we continue to gain the absolute truth? However, the sad thing is many people do not know or concern the horrors that control and power can bring to our society. Corporate journalism and corporate control of the cultural, information and entertainment complex have always existed. The media has been increased the political crises around the world. Take 911 as an example, the U.S. media devoted huge coverage to the attacks and their aftermath, but omitting a critical and accurate discussion of the context.5 The way which news broadcast, print, radio and Internet present news has a great effect on our emotion or feeling. Many Canadians are indignant as much as the Americans are when we heard that thousands people were killed by an airplanes hit in the World Trade Center. They support U.S to start the war against Iraqi because they are deeply influence by the mass media. The truth is, beside the reason of revenge and the elimination of terrorism, is the over taking of the petroleum a one of the reasons too? Countrys culture industries can be overwhelmed by foreign influence. The United States has always had stringent restrictions on foreign investment in its telecommunications and media sectors.6 Another negative effect of the mass media is the influence of the advertising have on us. Is advertising deceptive? Does it create or perpetuate stereotypes? Advertisements are everywhere in television, newspapers, magazines and internet. These media not only reflect our society, it also constantly reinforces certain ideas and human being.7 Companies and businesses often overwhelming the benefits and advantages of their products. They are willing to stretch and distort the truth, just to convincing people to buy their product. They may hide some facts such as the expensive price. For example, BMW ads amplify the amazing horsepower and the superior performance of their vehicles but will not mention how costly they are. Nike ads are accused of implying that their shoes will give a consumer athletic ability. The result is customers usually buy the things that they really do not need. Children most likely ask their parents to buy the toys and clothing after they have seen the commercial on the TV. It has created a stereotype, such as boys prefer to play robots and girls love dolls. Also, teenagers have become top consumers in todays society, so advertisers have focused on getting their business. Teens like to purchase new items to keeps up with the changing trends. Therefore, advertisers use their view of teens to create ads. Some ads may have bad effect on teenagers, such as alcohols and cigarettes. Although the concentrations of ownership, deregulation and technology have threatened our public interest, we can still able to learn about the choices that we face and make reasoned decisions. We have choice to see, to read, and to hear what we wanted to. It is up to the consumers to make wise choices and develop shopping skills that are intelligent. The one event may give rise to several news. People should learn to make an analysis of the truthfulness and express their own feeling but not influence by the media. BIBLIOGRAPHY: Chodos, Murphy, Hamovitch, Lost in Cyberspace, James Lorimer Company, Publishers, Toronto, 1997. Chomsky, Noam, Understand Power: The Indispensable Chomsky, The New Press, New York, 2002. Ermann, Williams, Shauf, Computers, ethics and society, Oxford University Press, New York, 1990. Gay, Martin k., The New Information Revolution, ABC-CLIO, Inc., California, 1996 Lorimer, Gasher, Mass communication in Canada, Oxford University Press, Canada, 2001. Mckibben, Bill, The age of missing information, Plume, Penguin Books Ltd, 1992. INTERNET RESOURCES: Global Media Markets and Citizen Information http://faculty.washington.edu/bennett/Media_Markets.htm Ansolabehere: Media Deregulation http://bostonreview.mit.edu/BR23.3/ansolabehere.html 1 Lorimer, Gasher, Mass communication in Canada, Oxford University Press, Canada, 2001, p.205. 2 Lorimer, Gasher, Mass communication in Canada, Oxford University Press, Canada, 2001, p.205. 3 ibid p.206 4 Chomsky, Noam, Understand Power: The Indispensable Chomsky, The New Press, New York, 2002, p.16. 5 Chomsky, Noam, Understand Power: The Indispensable Chomsky, The New Press, New York, 2002, p xiii. 6 Chodos, Murphy, Hamovitch, Lost in Cyberspace, James Lorimer Company, Publishers, Toronto, 1997, p.93. 7 Mckibben, Bill, The age of missing information, Plume, Penguin Books Ltd, 1992, p.17.
Wednesday, August 21, 2019
Informative Speech Essay Example for Free
Informative Speech Essay Shay McNealââ¬â¢s Secret Plot To Save The Tsar states that, On July 17, 1918, the Tsar, his wife, and their four daughters and ailing heir were led down to a basement in Ekaterinburg, Russia, and murdered in cold blood by a Bolshevik firing squad. The DNA analysis and identification of the bones were the conclusive proof the world was waiting for, and the case was considered closed. But is that the real story of the Romanovs? Good afternoon. Iââ¬â¢m Abby Cuenca and Iââ¬â¢ll share to you today the controversy in regards to the possible escape of Grand Duchess Anastasia Romanov to the Philippines from the 1918 execution. I will also discuss the evidences presented such as her similar picture with Czarina Alexandra Romanov, coincidental name, grandeur childhood and how she landed in the Pearl of the Orient Seas. Last May 2012, the Philippine Daily Inquirer published an article wherein a lady called Catherine is expressing the possibility that her grandmother could be The Anastasia of Russia. She wrote this article in search of her grandmamaââ¬â¢s, her nickname for her grandmother, lineage because she was intrigued ever since she was a child about her past. One thing is definite; Catherineââ¬â¢s grandmama is Russian but the rest of her story about whom she really is still a mystery to be unfold. At the end of my speech, I will be handing out some pictures and the copy of the article around for you to look at. Catherineââ¬â¢s journey of self-discovery started when she traveled to St. Petersburg on May 2009 to trace her Russian roots and to hopefully reunite with her grandmotherââ¬â¢s relatives when her mom mentioned the similarities between Czarina Alexandra Romanov and her grandmamma through the photographs Catherine emailed to her. For this reason, Catherine was able to piece together the information of what could be a story begging to be told. To begin with, Catherineââ¬â¢s grandmamaââ¬â¢s name is Tasia, a diminutive for Anastasia, which happens to be similar to one of the Czarââ¬â¢s daughter, Grand Duchess Anastasia Romanov of Russia. Second, her last name was Kazzuhina, or so how they say and spell it because no one in the family can pronounce it right. But suspiciously, Kazzuhina is similar Knyazhna, which comes from Grand Duchessââ¬â¢ Russian name, Velikaya Knyazhna Anastasiya Nikolayevna Romanova that means Duchess. So if Catherine is saying the truth, then how did the Duchess end up in the Philippines? Grandmama Tasia said she was 18 when she arrived in the Philippines after escaping the Bolshevik Revolution when it escalated in 1918. She disembarked in a Philippine port and brought to a monastery or orphanage somewhere in Manila, where nuns looked after her for some time until she met Catherineââ¬â¢s grandfather, Lope Pelayo. Furthermore, grandmama shared in her stories that ââ¬Å"she was the youngest of four daughters, and the fifth and youngest child of the family was the only boy, Alexei.â⬠She also mentioned on how they lived in a house surrounded by massive walls covered with jewels and enjoy the freshest butter, breads and cheeses because they were made right in their own house and how she rode around in a golden carriage drawn by eight white horses whenever she and her family traveled and that whenever Catherine and her siblings protested on how it all seemed a bit extravagant, she merely smiled and said that it was how they did things back then. But whatââ¬â¢s really intriguing is that, Tasia refuses to go out even to the supermarket or church and keeps on rejecting Catherineââ¬â¢s incessant pleas of writing to the Russian embassy about locating their Russian relatives. She always replies in a stern tone of warning: ââ¬Å"If they discover I am here, we will all be killed.â⬠What does this imply? The Romanov case will never be closed despite what some experts say. There will always be theories and stories that circulate and compel people about the truth behind what happened on the dawn of July 17, 1918. Catherineââ¬â¢s grandmamaââ¬â¢s story showing compelling evidences such as her name, similar faces, grandeur childhood and arrival to the Philippines is only a part of it. Remember, there will always be two sides of the story. The question is, which side do you believe on?
Immune Responses of Cytokine Adjuvented DNA Vaccine
Immune Responses of Cytokine Adjuvented DNA Vaccine KOTLA SIVAREDDY Title for the Ph.D Thesis ââ¬Å"Study on Immune responses of Cytokine Adjuvented DNA vaccine (genes coding for structural proteins) for FMD delivered by cationic PLG micro particlesâ⬠. Objectives: To clone gene coding for structural protein of FMDV in eukaryotic expression vector (pC DNA) under CMV promoter. To clone bovine interleukin 18 gene in suitable cloning vector and express the same in Bacterial/yeast expression system for characterization of expressed recombinant protein. To construct a vaccine construct consisting of FMDV P1 (structural), 3C (Viral protease), and Bovine interleukin 18 genes in eukaryotic expression system under CMV promoter (pC DNA). To study the expression of the vaccine constructs in vitro in BHK-21cells. PLG micro particlesââ¬â¢ preparation and characterization. To study the immune responses of the DNA vaccine in experimental animals (guinea pigs / cattle). Foot-and-mouth disease (FMD) caused by foot-and mouth disease virus (FMDV) is an infectious disease affecting cloven-hoofed animals, and poses a serious threat for animal health and exacts an economic toll on the livestock industry. FMD viral genome is a positive-sense single stranded RNA of approximately 8.5kb. The viral RNA genome is translated as a single polypeptide precursor that is subsequently processed by virus-encoded proteases 2A and 3C to produce the structural and non-structural proteins required for virus assembly and replication. One of the initial polypeptide cleavages, mediated by the 2A protein, is a co-translational cleavage at its own C terminus to release it from the 2B protein. The viral 3C proteinase subsequently processes the structural protein precursor, P1-2A, into the capsid proteins, VP0, VP3, and VP1, and the non structural peptide, 2A. These proteins then self assemble to form empty icosahedral capsid particles that contain 60 copies of each protein. Immu nological studies have identified linear and conformational sites that are present on both empty capsids and virions, and antiserum raised against either form has the same serological specificity. Thus, the structural protein precursor, P1-2A, and the 3C protease of FMDV are desirable immune antigens for new vaccine development. In countries where disease eradication has not been achieved, vaccination plays a crucial role in its control. Although inactivated virus vaccines effectively prevent FMD, they have several limitations like short duration of immunity, incomplete viral inactivation and virus escape from vaccine producing facilities. As a result, alternative approaches are being investigated, including the construction of modified live virus, subunit vaccines, synthetic peptides, naked DNA plasmids. DNA vaccination which offers several promising features i.e., DNA is convenient to manufacture and store, its production is safe, sequences from circulating strains can be easily i ncorporated in the vaccines, and it also allows the discrimination of the infected from the vaccinated animals. Several reports have shown the efficiency of DNA vaccination to induce protective immunity in the mouse model. However, the primary difficulty with DNA vaccination is its poor immunogenicity in target species. Cytokines are being used as molecular adjuvants by co administering with DNA vaccines to improve the efficacy of the vaccine. Cytokines play an important role both in the development of a functional immune system as well as in the responses of the organism to infection. Interleukin18 (IL18) is a potent interferon à ³ (IFNà ³) inducing factor (IGIF), enhances Th1 immune responses. Recent studies have shown that IL18 also promote Th-2 type responses and increases dendritic cell (DC) number in lymph nodes in mice. In addition, IL18 has been used as an adjuvant to DNA vaccines for classical swine fever virus, pseudo rabies virus, porcine reproductive and respiratory sy ndrome virus.IL18 was co expressed along with FMDV VP1 in Pichia as fusion protein has enhanced humoral responses and marginally the CMI response in mice. Recombinant fowl pox co-expressing FMDV P1 2A3C and IL18 enhanced the immune responses and gave higher protection in swine Many other studies have shown the positive effect of plasmid encoding the IL-18 as a molecular adjuvant on DNA vaccinations. Efficacy of DNA vaccine could be improved by the inclusion of adjuvants and good vaccine delivery systems. Importantly, cationic microparticle with adsorbed DNA induced enhanced immune responses in comparison to naked DNA and this enhancement was apparent in all species evaluated, including nonhuman primates. Cationic PLG microparticles appear to be effective predominantly as a consequence of the efficient delivery of the adsorbed DNA into DC. Following administration, the micro particles are also very effective at recruiting DC to the injection site, and the micro particles also protect adsorbed DNA against degradation in vivo. A second useful property of micro particles is that they can present multiple copies of antigens on their surface, which has been shown to be optimal for B cell activation. The main advantage of this type of association is the efficient immobilisation of plasmid DNA on the microparticle surface without compromising its integrity. Moreover, after administration, the release of cationic DNA complexes from the surface appeared to facilitate the transfection of cells .At this point, it is not completely understood, whether the adsorption on cationic micro particles can protect plasmid DNA from cleavage through endonucleases after administration in vivo. Nevertheless, release of cationic DNA complexes is expected to provide better protection as compared to release of free DNA. Beside their inherent safety and ease of administration, they improve the DNA capture by antigen presenting cells (APC) and stimulate APC maturation. DNA delivery via PLG has been successfully used to vaccinate against several infections in mice, guinea pigs and even in macaques models. 1. AMPLIFICATION and cloning of gene sequence coding for P12A 3C FMDV serotype ââ¬ËAsia1ââ¬â¢ gene coding for the polyprotein, P1-2A (2.3 kb) was amplified from viral genome, of the serotype ââ¬ËAsia1ââ¬â¢ polyprotein gene, using VP4L (Bac) and 2AR (E.coR1) primers. Cloned in to pC DNA at E.co R I, BamHI sites. Ligated and transformed in to DH alpha 5 cells. Transformants are screened by colony PCR by using insert specific primers. Orientation was checked by PCR. Insert release was confirmed by RE digestion by using E.co R I, Bam HI. 3C coding sequences were amplified from clone available in lab. 0.6 Kb was amplified .The purified amplicon was digested and ligated in to p C DNA and transferred in to competent DH5à ¯Ã à ¡ cells upon screening by PCR and by re digestion positive clones were conformed. 2. Cytokine amplification (IL18) and cloning in prokaryotic / yeast pC DNA expression vector and characterization of expressed protein. Interleukin 18 (IL18) modulates immune functions by inducing interferonââ¬âà ³(IFN-à ³) production and promoting Th1 immune responses. In the present study I amplified and cloned the sequence (582 bp) encoding full length bovine IL18 from peripheral blood mononuclear cells (PBMC) stimulated with Phytohaemoglutinin (PHA). Nucleotide and the deduced amino acid sequence of the cloned IL18 showed an identity of 86-98% with IL 18 sequences of the other ruminants compared. The insert was sub cloned in to eukaryotic expression vector (PcDNA) .The specificity of the expressed IL 18 was confirmed by western blotting. The insert was sub cloned in to pET 32a vector and expressed in E.Coli as fusion protein of 42kDa. The specificity of the expressed IL 18 was confirmed by western blotting. The biological activity of the purified protein was analysed for its ability to induce IFN-à ³ production in PBMC as measured by Enzyme linked immunosorbent assay (ELISA) and quantitative polymerase cha in reaction (qPCR). IL18 anti FMD viral activity was conformed in vitro in BHK-21 cells by using plaque assay; viral replication was quantified by Real time PCR, ELISA and titration assays. 3. Study of the expression of the constructs in vitro in BHK-21 Cells Expression of cloned P12A3C and IL18 genes were studied in mammalian expression system for confirming the frame and intactness. The P12A3C, IL18 genes cloned under Eukaryotic promoter was transfected in BHK 21 cells with lipid based lipofectamine. Subsequently, the proteins were confirmed by Western blotting by using using anti FMDV serotype ââ¬ËAsiaââ¬â¢, serum from experimentally infected cattle. IL18 transfected cell lysate showed 18 KDa by using human IL18 Mab. 4. PLG microparticles preparation and characterization The PLG/CTAB micro particles were prepared using a solvent evaporation technique essentially as described previously and briefly, the micro particles were prepared by emulsifying 10ml of a 6% (w/v) polymer solution in methylene chloride with 1ml of TE buffer at high speed using an soniprep. The primary emulsion was then added to 50ml of distilled water containing CTAB (0.5%, w/v). This resulted in the formation of a water/oil/water emulsion which was stirred at 6000rpm for 12h at room temperature, allowing the methylene chloride to evaporate. The resultingmicro particles were washed in distilled water by centrifugation at 10,000 Ãâ" g and freeze dried. The plasmid construct was adsorbed onto the microparticles by incubating 100 mg of cationic microparticles with 100 mgs (1 mg/ml solution) of plasmid DNA at 40C for 6 h. The coated microparticles were then separated washed with TE and freeze-dried. Amount of plasmid adsorbed on PLG particles was quantified by eluting the DNA by 0.2 N NaOH (incubation for 10 h at 4 0C and measuring the Optical Density (OD) at 260 nm. Blank PLG micro particles controls were run simultaneously to deduct background value. The size distribution of the micro particles was determined using a particle size analyzer and electron microscopy. 5.A. Evaluation of the Immunological response of various DNA vaccine constructs in guinea pigs. Foot and Mouth Disease (FMD) can be controlled by regular vaccination and restricting the movement of animals infected in the endemic countries.. DNA vaccine construct was made with P1-2A3C coding sequences of serotype Asia1 in p C DNA. To evaluate the optimal dose of the construct in guinea pigs, the plasmid was coated on cationic Poly Lacto-co-Glycolide (PLG) micro particles was injected in to guinea pigs at 2,5,10,15,20,30 ug doses intramuscularly. Sera samples collected from the vaccinated animals at 21st dpv were evaluated for immune response by Enzyme linked immunosorbent assay (ELISA), Serum neutralization test (SNT) and MTT assay. Maximum ELISA / SNT titers and MTT stimulation indices were observed at 10 à µg dose which also gave 83% protection when the guinea pigs were challenged with homologues virus. 10ug was found to be the optimal dose to guinea pigs. P12A3CpCDNA and bovine IL-18 pcDNA plasmids were constructed under CMV promoter and the coated with Cationic PLG microparticle, immune response of the co administered constructs was evaluated in guinea pigs. Both the plasmids constructed under CMV promoter and 10à µgs each of the plasmids were inoculated intra muscularly in guinea pigs with a booster dose at 21st day post vaccination (dpv). Both humoral and cellular immune response were analysed by IgG1, IgG2 enzyme linked immunosorbent assay (ELISA), Serum neutralization test (SNT) and MTT assay. Th1, Th2 cytokine profile was analysed by real time PCR and the phenotyping of T cell sub population in the peripheral blood was performed by flowcytometry. The results have sown significantly higher humoral and cell mediated immune responses in P12A3CIL18+PLG group than P12A3C IL18, and inactivated virus vaccine inoculated groups. Similarly, higher CD4, CD8 population and Th1, Th2 cytokine levels were seen in former group. P12A3CIL18+PLG vaccine protected all the six animals when challenged with homologous virus compared to five in inactivated virus vaccine group respectively. These results have shown that the plasmid encoding for P12A3C pcDNA when co inoculated with IL18 and PLG induce higher and protective immune responses, suggesting rBoIL-18 and Micro particles has a potential to enhance the efficacy of vaccine against FMD. 5. B Evaluation of the Immunological response of various DNA vaccine constructs in Cattle. Healthy male cattle calves of local breed ( Hallikar Breed) of 6 months to one year age group were purchased from local village shandy( cattle market). These animals were housed in healthy animal shed facilities available at IVRI Animal experimental station at Yelahanka , Bangalore. After initial quarantine the animals were bled and the sera were screened for FMDV antibodies for serotype Asia 1 by SNT. The FMD antibody free animals were divided in to 6 groups of six animals each namely Group I to Group IV. All the group were vaccinated with each construct with 200 ug injected by intramuscularly except conventional vaccine group injected with 2 ml of FMDV Inactivated vaccine. One group kepted for control group (vaccinated with PBS) .After 21 st days of first vaccination with same amount booster dose was injected P12A3CpCDNA and bovine IL-18 pcDNA plasmids were constructed under CMV promoter and the coated with Cationic PLG microparticle, immune response of the co administered constructs was evaluated in guinea pigs. Both the plasmids constructed under CMV promoter and 200à µgs each of the plasmids were inoculated intra muscularly in calves with a booster dose at 21st day post vaccination (dpv). Both humoral and cellular immune response were analysed by IgG1, IgG2 enzyme linked immunosorbent assay (ELISA), Serum neutralization test (SNT) and MTT assay. Th1, Th2 cytokine profile was analysed by real time PCR (à ³IFN, IL4, IL2, à ±IFN, IL12, IL25,TLR-4,TLR3,TLR-2,IL8,IL10) and the phenotyping of T cell sub population (CD4 and CD8) and intracellular cytokine molecules (à ³IFN, IL4, IL2) in the peripheral blood was performed by flowcytometry. The results have sown significantly higher humoral and cell mediated immune responses in P12A3CIL18+PLG group than P12A3C IL18, and inactivated virus va ccine inoculated groups. Similarly, higher CD4, CD8 population and Th1, Th2 cytokine levels were seen in former group. P12A3CIL18+PLG vaccine protected four out of six animals when challenged with homologous virus compared to 3 in inactivated virus vaccine group respectively. Non structural proteins,ELISA conformed in challenged animals.These results have shown that the plasmid encoding for P12A3C pcDNA when co inoculated with IL18 and PLG induce higher and protective immune responses, suggesting rBoIL-18 and Micro particles has a potential to enhance the efficacy of vaccine against FMD Journal papers and conference/seminar papers from Doctoral research work 1. Expression of Bovine (Bos indicus) interleukin-18 inEscherichia coli and its biological activity.Kotla Siva Reddy, Dowlathabad. Muralidhar Rao, Hosur Joyappa Dechamma,Veluvarthy V.S. Suryanarayana and Golla Ramalinga Reddy.Published in Microbiology and Immunology 2010; 54: 564ââ¬â567. 2. Enhancement of DNA vaccine (P12A3C-pcDNA) efficacy against Foot- andMouth Disease by co-administration of Interleukin-18 expressing (IL18pcDNA) plasmid in Guinea Pigs. Siva Reddy .K. Muralidhar Rao.D., Badrinaryana.M. Suryanaryana.VVS. and Reddy G.R. Accepted in FEMS Immunology and Medical Microbiology. Dec -2010 1ââ¬â9. 3. Dose optimization of Cationic PLG micro particle coated DNA vaccine against Foot and Mouth Disease in Guinea pigs. Siva Reddy, K.,Rashmi., B.R., Muralidhar Rao, D., Dechamma H.J., Banumathi .N., Suryanarayana V.V.S and Reddy .G.R. accepted in J.of Life science.(Article in press) 4. Cytokine profile studied by Real time PCR in FMDV antigen stimulated Bovine PBMC cells. Siva Reddy .K., Muralidhar Rao,D.,PrabhuDas,K., Suryanaryana.VVS., Reddy ,G.R. Accepted in Journal of Biotechnology , Bio engineering and Bio ââ¬âInformatics. (Article in press). 5. Bos indicus Interleukin 18 complete coding sequence published in NCBI Gen bank .SivaReddy,K., Muralidhar Rao,D., Dechamma,H., Banumathi,N.,Suryanaryana,V. and Reddy,G. Acc.No. FJ985771 6. Enhancement of DNA vaccine (P12A3C-pcDNA) efficacy against Foot- andMouth Disease by co-administration of Interleukin-18 expressing (IL18pcDNA) plasmid in Guinea Pigs. Siva Reddy .K. Muralidhar Rao.D., Badrinaryana.M. Suryanaryana.VVS. and Reddy G.R. Presented in Society for applied biotech biotechnology (SAB) annual conference at Dharmapuri Dec 17,18 7.Bovine Interleukin -18 inhibits Foot-and-Mouth Disease virus Replication in BHK- 21 cells. K. Siva Reddy, D.Murali Dhar Rao, Kakoli Ahmed, H.J Dechamma N.Bhanumathi ,VVS Suryanarayana ,G.R Reddy presented at VIROCON 2010 XIX National Conference RECENT TRENDS IN VIRAL DISEASE PROBLEMS AND MANAGEMENT SVU Tirupathi, Mar 18-20 ,2010 . 8. Cationic Micro Particle (PLG) coated DNA vaccination Induces a long term immune response and Protective Immunity against Foot ââ¬âand-Mouth disease virus. K. Siva Reddy, Rashmi Dechamma N.Bhanumathi ,VVS Suryanarayana ,G.R Reddy Presented at VIROCON 2010 XIX National Conference RECENT TRENDS IN VIRAL DISEASE PROBLEMS AND MANAGEMENT SVU Tirupathi, Mar 18-20 ,2010. 9. Dose response studies of ID- p VAC (SECRETORY VECTOR CONSTRUCT) coated on cationic PLG micro particles against FMDV in guinea pigs. Siva Reddy K., Reddy G.R. Presented at SBC Annual conference Impact of Basic and Translational Research on Medicine, Agriculture and Industry, IIT Madras 18-20 DEC -2008. Communicated Articles 1. Cationic Micro Particle (PLG) coated DNA vaccination induces a long term immune response and Protective Immunity against FMD in GuineaPigs. Siva Reddy ,K ., MuraliDhar Rao,D.,Rashmi, B.R., Dechamma H,J., Banumathi.,N., Suryanarayana V.V.S and Reddy G.R Communicated in to Vet Immunology and Immunopathology(Under review). 2. Bovine Interleukin 18 inhibits Foot and mouth disease virus replication in BHK-21 Cells. K. Siva Reddy, D.MuraliDhar Rao, K.PrabhuDas, VVS Suryanarayana,G.R Reddy communicated in to Biotechnology and Applied Biochemistry. 3. Enhanced efficacy of a Foot and mouth disease DNA vaccine (P12A3CpcDNA) by adsorption onto cationic PLG microparticle in guinea pigs .K. Siva Reddy, D.MuraliDhar Rao, K.PrabhuDas, VVS Suryanarayana ,G.R Reddy communicated into International journal of Immunopharmacology.
Tuesday, August 20, 2019
Teen Pregnancy Essay -- Teenage Mothers
In the US, teen pregnancy rates have been decreasing in the last decade even though current rates remain twice as high as those found in other industrialized nations (Alan Guttmacher Institute, 1994). In spite of decreasing rates, among African American teenagers, the pregnancy rate is particularly high. In 1996, the pregnancy rate was 178.9 per thousand among African-American females aged 15 to 19 years, compared with a pregnancy rate of 82.6 among whites (Alan Guttmacher Institute, 1999). Additionally, on the basis of the findings of the 1995 National Survey of Family Growth, it was determined that African American females (48%) aged 15 to 17 were more likely than their white (34%) counterparts to have had sexual intercourse since menarche. On the basis of information provide by the National Center for Health Statistics (1997), African-American females aged 15 to 19 were more likely than their white peers to have had their first sexual experience (i.e., intercourse) without u sing effective contraception (24% versus 14%, respectively). Consequently, on the basis of such risky behavior, African American teenagers are at greater risk than their white peers for experiencing a pregnancy. pregnant, especially if it was with the baby's father. A concluded by Harris, most of the mothers believed that sexual intercourse was a behavior they were going to continue to engage in, regardless of threat of disease or pregnancy. As compared to the adolescent fathers participating in the study, Harris reported that most of the fathers indicated that they were now engaging in protected sex. Environmental Influences As many have suggested, while engagement in unprotected sexual intercourse at an early age places adolescents at risk for pregnancy, there are a number of other factors that influence African American teen pregnancy rates. According to Dervarics (2004), African American teen mothers and fathers are often represented among the rising number of minority "disconnected" youth in the US. This group is comprised of teens ages 16 to 19 who are both out of school and out of work. Dervarics reported that nearly A quarter of African Americans ages 18 to 19 falls into the disconnected category. As a consequence of being disconnected, as explained by the author, African Amer... ...with poverty. It is these issues that attention must be directed towards in order to reduce teen pregnancy rates. References Alan Guttmacher Institute. (1994). Sex and America's teenagers. NY: The Alan Guttmacher Institute. Alan Guttmacher Institute. (1999). Teenage pregnancy: Overall trends and state-by-state information. NY: The Alan Guttmacher Institute. Dervarics, C. (2005). Minorities overrepresented among America's 'disconnected' youth. Population Reference Bureau. Found online at: http://www.prb.org/Template.cfm?Section=PRB&template=/ContentManagement /ContentDisplay.cfm&ContentID=11335 Lardner, J. (2005). Arline Geronimus on teen parenthood. Inequality.Org. Found online at: http://www.inequality.org/teenparenthood.html National Center for Health Statistics. (1997). Fertility, family planning, and women's health: New data from the 1995 National Survey of Family Growth. Hyattsville, MD: National Center for Health Statistics.
Monday, August 19, 2019
Comparison of Platos The Last Days of Socrates and Hesses Siddhartha
Comparison of Plato's The Last Days of Socrates and Hesse's Siddhartha à à The Last Days of Socrates and Siddhartha are sources that reveal information about religious or philosophical ideas in the cultures that they focus on. While vast differences exist between the Greek and Indian values that shape their philosophies, they make similar assumptions as they attempt to make sense of the world. Understanding the dichotomous relationship of the soul and the body is integral to grasping the similarities and differences between the classical Greek and Indian paths because the way in which these concepts are understood defines the very nature of truth. à Socrates, the main character in The Last Days of Socrates, and Siddhartha, the central figure in Siddhartha, are both portrayed as learned men searching for truth. The author of The Last Days of Socrates, Plato, conceived the document as a representation of Socrates' method of inquiry. Although it is a primary source from the period (429-347 B.C.E.), the reader must consider that The Last Days of Socrates is a re-creation of events that may have happened, not a verbatim account. Siddhartha is a secondary source that explains an Indian philosophical journey through the perspective of a twentieth century German author. Thus, one must consider the author's bias towards his subject and remember that the ideas presented are one scholar's interpretation of the legend. By attempting to compare and contrast both sources' approaches to truth, one can make some observations about the way Greek and Indian cultures view truth; keeping in mind that the sources each merely represent one account of the historical events and ideas. à Intrinsic to Siddhartha and Socrates' searche... ...th. By becoming aware of the separation of the soul and the body, the indestructible and immortal nature of the soul, and the impossibility of the soul understanding truth while bound to the body, one can begin to understand how this dichotomy has shaped Indian and ancient Greek philosophy. à Works Cited Baumer, Franz.à Hermann Hesse.à New York: Frederick Ungar Publishing Co., 1970. Field, G.W.à Hermann Hesse.à Boston: Twayne Publishers, 1970. Hesse, Herman. Siddhartha. Dover Publications, 1998. Plato, The Last Days of Socrates.à Trans. Hugh Tredennick and Harold Tarrant.à London: Penguin, 1993. Welch, Carolyn Roberts.à Cliff's Notes on Hesse's Steppenwolf and Siddhartha. Lincoln: Cliff's Notes Inc., 1973. Ziolkowski, Theodore.à The Novels of Hermann Hesse: A Study in Theme and Structure. Princeton: Princeton University Press, 1965.
Sunday, August 18, 2019
Analysis of The Complete English Tradesman :: Complete English Tradesman Essays
Analysis of The Complete English Tradesman Daniel Defoe's "The Complete English Tradesman", is a good example of his non-fiction writing. The content in the writing is thorough and well presented by Defoe. In the writing, Defoe explains what his opinions on what it means to be an English tradesman. Contrary to some experienced tradesmen, he believes that to be a good tradesman, one needs to acquaint himself with all business in general. According to Defoe, application is of more importance than diligence in business. "Without application nothing in this world goes forward as it should.." Tradesmen of Defoe's day said that there needs to be an aggressive passion in how one handles business, and anger and temper sometimes are necessary. Defoe also challenges this. He believes a "complete tradesman" should not show the least return, signal of disgust, no passions or fire in his temper. A complete tradesman should be soft and smooth, showing little emotion. Basically, Defoe explains how to be by his definition a complete tradesma n. "When a tradesman has thus conquered all his passion, and can stand before the storm of impertinence, he is said to be fitted up for the main article, namely, the inside of the counter." The content of the writing is very comprehensive, covering many aspects of being a tradesman. The content that has already been praised, is presented very well. Defoe organizes the information into letters to all tradesman of England. The writing is a collection of letters to English tradesman, each addressing a different issue. Defoe makes it clear that the information is based on opinion, so there are no false leads. For example, "It its the judgment of some experienced tradesman that no man ought to go form one business to another... I, myself will not enter that dispute here. I know some very encouraging..." Defoe also provides examples by making a story using a script format. "Lady. No I can't he'd use me. Cit. How does your ladship know? Lady. Why, I know...." Defoe uses different techniques and ideas to present the content well in this piece. In Daniel Defoe's "The Complete Tradesman", the description usage is adequate, but in a few cases it is a little too much. There is enough description to explain the whole situation, but it is not overdone to tire the reader.
Saturday, August 17, 2019
Authentic Freedom Essay
A human being is free to do as what they please! Thatââ¬â¢s just an interpretation of authentic freedom. All too often humans think of freedom as a free for all. Authentic freedom is does not mean doing what one wants when one wants to whom one wants, but rather it means, understanding who one is , that a human being is not alone and here to contribute to society. Authentic freedom is a paradox, one that will make you think, but not a contradiction. The more freedom a human being has, the more one is called to respond. ââ¬Å"Freedom is exercised in relationships between human beings. Every human person, created in the image of God, has the natural right to be recognized as a free and responsible being. All owe to each other this duty of respect. The right to the exercise of freedom, especially in moral and religious matters, is an inalienable requirement of the dignity of the human person. This right must be recognized and protected by civil authority within the limits of the common good and public order (Catechism, 1732). A human being gains freedom, by exercising freewill in a positive and productive way. People make choices in daily life, choices that affect the ability to live a free life. When one chooses to go counter to the common good, a human being chooses slavery, slavery to the consequences of oneââ¬â¢s choice. â⬠The more one does what is good, the freer one becomes. There is no true freedom except in the service of what is good and just. The choice to disobey and do evil is an abuse of freedom and leads to ââ¬Å"the slavery of sinâ⬠(Catechism, 1733). When a human chooses not to listen to their conscience one chooses to listen to the voice of evil, when that happens, a human being has just entered in to a slave/master relationship. With them being the slave. Freedom allows one to make choices that benefit themselves and more importantly the world around them. Freedom demands of one, or rather obligates one to concern ourselves with the affairs of the world around us. If you look at the world around a human being, countries where freedom is lacking, the overall population is less concerned with their fellow man, then in a freer society. The same can be said of individuals, the more freedom a human being has, and the more responsible one acts to other, on the whole.
Friday, August 16, 2019
The Management Of Chronic Prostatitis Health And Social Care Essay
A sum of 124 patients with chronic prostatitis were followed in urogenital medicine clinic at Prince Rashid Military Hospital from January 2006 to process 2010. Merely 98 patients completed the survey and were divided into two groups ; group A managed with ?-blockers and group B with placebo.ConsequencesThere was same response rate in both groups, with 48.7 % lessening of at least 4 points in their entire NIH-CPSI mark from base line to 6 hebdomads.DecisionWe found that ?-blockers are non helpful in the direction of chronic prostatitis. ( Rawal Med J 2011 ; 36:294-296 ) .Key wordsProstatitis, alpha blockers,IntroductionProstatitis is considered to be one of the common causes of visit to urology clinic. It accounts for 3-8 % of out patients visit to urology clinics in North America and Europe.1-3 It is classified into four subtypes harmonizing to National Institution of Health ( NIH ) : Type I: acute bacterial prostatitis, Type II: chronic bacterial prostatitis, Type III: chronic pros tatitis, chronic pelvic hurting syndrome ( CPCPPS ) , which is the commonest type, and Type IV: symptomless inflammatory prostatitis.4-6 ?-Blockers have been used to handle the symptoms of chronic prostatitis every bit good as benign prostate hyperplasia by virtuousness of their consequence on the musculuss of prostate and vesica neck.6 These are one of three commonest prescribed medical specialties by urologists for chronic prostatitis i.e antibiotics, alpha blockers and anti inflammatory drugs.7 The purpose of this survey was to measure the function of ?-blockers in intervention of chronic prostatitis.Patients AND METHODSA sum of 124 patients of chronic prostatitis were followed in urogenital medicine clinic at Prince Rashid Military Hospital between January 2006 and March 2010. Merely 98 patients completed the survey. We divided the patients into two groups ; group A ( 49 patients ) managed with ?-blocker Doxazosin 4mg one time day-to-day and group B ( 49 patients ) used placebo. The period of the survey lasted for 6 hebdomads. We used the National Institutes of Health Chronic Prostatitis Symptom Index ( NIH-CPSI ) 4 to mensurate the betterment of our patients. NIH-CPSI takes into history hurting symptoms, urinary symptoms and impact on quality of life, with a entire mark of ( 0-43 ) . We measured the mark for our patients before and after intervention. Patients were classified as respondents if there was 4 points or more betterment and non respondents if less than 4 points were achieved. In both groups, patients ages are symmetrical ( 27-45years ) ,ConsequenceOf 124 patients, 26 patients did non complete with the survey, merely 98 patients did. The ages of patients range from 27 twelvemonth to 45 old ages ( average 39 old ages ) . All patients were married. 48.7 % work forces on alpha blocker showed a lessening of at least 4 points in their entire NIH-CPSI mark at 6 hebdomads. There was about same rate of response in patients on placebo. At planetary response, we did non happen any important difference ( p=0.7 ) or alterations over clip in the secondary result between the two groups, ( 32.4 % vs33.6 % ) .DiscussionChronic prostatitis patients experience a hard and worse quality of life than patients enduring from benign prostate hyperplasia or even most of patients with prostatic cancer.5 ?- Blockers are considered to be an of import mode of intervention of chronic prostatitis/chronic pelvic hurting syndrome, as several surveies have shown that they improve symptoms of chronic prostatitis and diminish the hazard of urine retention.8-10 Cheah et al did a randomized survey on 86 patients with chronic prostatitis utilizing ?- blockers and placebo, and reported important response with 50 % decrease in the mean symptoms score compared to 37 % in placebo.8 A 65 % betterment of symptoms in comparing with merely 42 % with placebo,9 and 52 % response with ?- blockers compared with 33 % with placebo have been reported.10 On the contrary, no important response with ?- blockers in chronic prostatitis was obtained by Alexander et Al who did a big multicenter randomized test of intervention on patients with CPCPPS in two groups, one with Cipro and ?-blockers, other group with placebo. They found no difference among these drugs, either glandular fever or multi therapy intervention of CPCPPS.11DecisionIn our survey, our findings did non back up usage of ?-blockers, in handling chronic prostatitis. Correspondence: Awad B Al-kaabneh. Electronic mail: awadalkaabneh @ gmail.com Received: April 07, 2011 Accepted: September 26, 2011Table 1. NIH-Chronic Prostatitis Symptom Index ( NIH-CPSI )Pain or Discomfort1. In the last hebdomad, have you experienced any hurting or uncomfortableness in the following countries? Yes No a. Area between rectum and 1 0 testiss ( perineum ) b. Testicles 1 0 c. Tip of the phallus ( non related to 1 0 micturition ) d. Below your waist, in your 1 0 pubic or bladder country 2. In the last hebdomad, have you experienced: Yes No a. Pain or combustion during 1 0 micturition? B. Pain or uncomfortableness during or 1 0 after sexual flood tide ( interjection ) ? 3. How frequently have you had hurting or uncomfortableness in any of these countries over the last hebdomad? 0 Never 1 Rarely 2 Sometimes 3 Often 4 Normally 5 Always 4. Which figure best describes your Average hurting or uncomfortableness on the yearss that you had it, over the last hebdomad? 0 1 2 3 4 5 6 7 8 9 10 No hurting Pain bad as you can conceive ofMicturition5. How frequently have you had a esthesis of non emptying your vesica wholly after you finished urinating, over the last hebdomad? 0 Not at all 1 Less than 1 clip in 5 2 Less than half the clip 3 About half the clip 4 More than half the clip 5 Almost ever 6. How frequently have you had to urinate once more less than two hours after you finished urinating, over the last hebdomad? 0 Not at all 1 Less than 1 clip in 5 2 Less than half the clip 3 About half the clip 4 More than half the clip 5 Almost everImpact of Symptoms7. How much hold your symptoms kept you from making the sorts of things you would normally make, over the last hebdomad? 0 None 1 Merely a small 2 Some 3 A batch 8. How much did you believe about your symptoms, over the last hebdomad? 0 None 1 Merely a small 2 Some 3 A batchQuality of Life9. If you were to pass the remainder of your life with your symptoms merely the manner they have been during the last hebdomad, how would you experience about that? 0 Delighted 1 Pleased 2 Largely satisfied 3 Mixed ( about every bit satisfied and dissatisfied ) 4 Largely disgruntled 5 Unhappy 6 AwfulScoring the NIH-Chronic Prostatitis Symptom Index DomainsPain: Sum of points 1a, 1b, 1c,1d, 2a, 2b, 3, and 4 = Urinary Symptoms: Sum of points 5 and 6 = Quality of Life Impact: Sum of I
Business operational Essay
To provide learners with an understanding of the role and importance of operations management (OM) in the efficient and effective production of goods and services. Scenario: WH Smith is a major, well-known and publically-quoted book retailer and newsagent in the UK. Recently it was reported how Kate Swann, the former CEO for the last 10 years, has turned the company around from ? 135m losses to ? 106m profit in a decade. (source: www. theguardian. com/business/blog/2013/jan/23/wh-smith-kate-swann-profit, accessed 1 October 2013) (Also see copy attached) This is an example of how the principles of operations management can be used to reactivate a firm. How did she do it? Using the above as a starting point, together with other information sources, which you should research yourself, on WH Smith, you are asked to address the Tasks below regarding operations management. Task 1 (this meets LO 1, ACs 1. 1, 1. 2 and 1. 3) Based on the Scenario, produce a document explaining the nature and importance of Operation Management and its key elements. Your document for this Task must include the following elements (among others as you wish): I. A definition of OM and an explanation of its importance; II. The key elements of OM; III. The need to produce goods or services on time and to cost, with the right quality and within the law; IV. The role of OM in achieving strategic objectives; and V. Produce systems and sub-systems diagrams for any WH Smith operations processes, including a brief explanation of your diagrams. Task 2 (this meets LO 2 ACs 2. 1, 2. 2 and 2. 3) Based on the Scenario, produce a document explaining the relationship between OM and strategic planning. Your document for this Task must include the following elements (among others as you wish): I. II. III. Explain the implementation of the ââ¬Å"3Esâ⬠in WH Smith; Critically review the tension between cost minimisation and quality maximisation in the context of WH Smith; and Assess the importance of the five performance objectives that underpin operations management. Task 3 (this meets LOs 3 and 4 in full) Base on the Scenario, produce a document explaining how to organise and apply relevant techniques in a typical production process. Your document for this Task must include the following elements (among others as you wish): I. II. III. IV. Comment briefly on the importance of operational planning and control. Explain what linear programming is, and give an example in relation to any part of the operations of WH Smith; Produce a network plan and indicate the resultant critical path for any operation in WH Smith. (for this task, you should include a set of operational outcomes, which are clearly defined). Explain how quality can be defined and maintained. Learning Outcomes and Assessment Criteria In order to Pass this unit, the evidence that the learner presents for assessment needs to demonstrate that they can meet all the Learning Outcomes for the unit. The Assessment Criteria determine the standard required to Pass this unit. The Assessment Criteria will act as a guide to help you put into context your answers to fulfill the Learning Outcomes. Learning Outcome Assessment Criteria 1. 1 explain the importance of operational management 1. 2 explain the need to produce safely; on time; to cost; to LO 1Understand the quality and within the law nature and importance 1. 3 explain the link between operations management and of operational strategic planning management 1. 4 produce a systems diagram to illustrate a typical business 2. 1 explain the ââ¬ËThree Esââ¬â¢ (economy, efficiency and effectiveness) LO2 Understand the link between operations 2. 2 explain the tension between cost minimisation and management and quality maximisation strategic planning 2. 3 evaluate the significance of the five performance objectives that underpin operations management 3. 1 explain linear programming LO3 Understand how 3. 2 evaluate critical path analysis and network planning to organise a typical 3. 3 explain the need for operational planning and control production process LO4 Be able to apply relevant techniques to the production of an operational plan for a typical business 4. 1 produce a set of clearly defined operational outcomes 4. 2 produce a network plan and indicate the resultant critical path 4. 3 explain how quality could be defined and maintained. INSTRUCTIONS AND INFORMATION FOR LEARNERS This assessment and the Tasks above are designed to assess your achievement of all four of the Learning Outcomes and associated Assessment Criteria for a Pass in the ââ¬ËEmployability Skillsââ¬â¢ unit of the qualification you are undertaking. Your tutor/ deliverer will advise you when you should start work on the assignment, the date when you must hand in your completed work and when you can expect to get your mark and feedback on your work. Guidance on this subject is provided on page 1 of this assignment brief. You should make sure that you plan your work carefully, to ensure that you cover all four learning outcomes of the assignment, and complete it within the time limit specified. There is no official guideline wordcount or percentage marking (other than Pass/ Merit/ Distinction/ Refer). By way of guidance only for this particular assignment, it is recommended that you write a minimum of 2000-2500 words total and match the weighting of your efforts to the wordcount indicated. Your statements in answer to the Learning Outcomes need to be prefixed with the specific Learning Outcome title or at least the Learning Outcome number. This will help you keep on track and should ensure you address the details. You must make sure that you acknowledge any sources you have used to complete this assignment, listing reference material and web sites used. The assignment result will be published on BITEââ¬â¢s Moodle online education materials platform, normally within 6 weeks of the submission date. If your assignment is assessed as referred, you will be notified with an indication of the areas to be addressed. You may resubmit an assignment, or submit a new assignment, on a further two occasions during your period of registration as an Institute learner with Edexcel. If there is anything in these instructions or in the assignment itself which you do not understand, please seek guidance from your tutor/ deliverer. Merit grade Descriptors For learners to achieve a Merit they must: Identify and apply strategies to find appropriate solutions Indicative characteristics Learners must demonstrate that: An effective approach to assignment planning, study and research is in evidence Evaluations and judgements, using evidence, have been made Problems with a number of variables have been considered Select/design and apply appropriate methods/techniques A range of relevant theories have been included Relevant theories and techniques have been applied to the case study A range of different sources of information have been used The selection of methods/techniques of analysis and use of source material have been justified Information/ data has been synthesised and processed Present and communicate appropriate findings The written assessment is coherent, shows logical development and a sound understanding of theories, concepts and research evidence The written assessment demonstrates that an appropriate structure and approach has been used The written assignment demonstrates a writing style appropriate for audiences both familiar and unfamiliar with the subject. The written work is clearly written and technical language has been accurately used Distinction grade Distinction descriptors For learners to achieve a Distinction they must: Indicative characteristics Learners must demonstrate that: Use critical reflection to evaluate own work and justify valid conclusions. Conclusions have been arrived at through synthesis of ideas and evaluation of research evidence and have been justified The validity of results has been evaluated using defined criteria Realistic and informed recommendations have been proposed against defined characteristics for success Take responsibility for managing and organising activities. The written assignment shows excellent planning, is organised coherently and is clearly expressed Independence of thought and gathering of research material has been demonstrated Material used has been clearly understood and well organised The importance of individual and group behaviour in organisations and its management has been recognised and addressed Demonstrate convergent/lateral/creative thinking. There is evidence of self-generated ideas with evaluation Convergent and lateral thinking are evident in the written assignment Creative thinking is evidenced with unfamiliar material. Problem-solving is in evidence Innovation and creative thought are in evidence Receptiveness to new ideas is evident Ideas have been generated, evaluated and informed decisions/ recommendations are made. Case Study: WHSmith â⬠¢ WH Smith: Kate Swann turns ? 135m losses into ? 106m profit in a decade One of the UKââ¬â¢s most highly regarded ââ¬â and highly paid ââ¬â retailers achieved success by going against the grain WH Smith chief executive Kate Swann favours the old retail adage: sales are vanity, profits are sanity. Photograph: PA When Kate Swann arrived at WH Smith in 2003, there was a widely held view that the chainââ¬â¢s days were numbered. A decade on, she has turned losses of ? 135m into a profit of probably ? 106m this year, and shares that were languishing at 250p are now changing hands at 650p. Swann is now one of the UKââ¬â¢s most highly regarded ââ¬â and highly paid ââ¬â retailers. Yet she has achieved this remarkable feat by breaking many of the ââ¬Å"rulesâ⬠of running a successful high street retail business. When Swann announced she was pulling out of selling music and DVDs because the profit margins were thin and getting thinner, rivals thought she had taken leave of her senses ââ¬â she was instantly kissing goodbye to about 30% of Smithââ¬â¢s turnover. On a same-store basis on the high street, WHS now sells roughly ? 65 of goods for every ? 100 of custom seven years ago. The demise of Zavvi and HMV in the face of online competition shows it was a brave ââ¬â and correct ââ¬â decision. Swann favours the old retail adage: sales are vanity, profits are sanity. By focusing on profitable sales and cutting costs relentlessly, she has boosted profit margins ââ¬â according to analyst Nick Bubb by an almost incredible 15 percentage points. While other retailers have been pouring resources into the digital world, Smithââ¬â¢s big online strategy is its Funky Pigeon card site. Instead, Swann plans to open more shops, even though they are, to be frank, deeply unpleasant places to shop, stuffed with stock and screaming promotional banners. While the supermarkets have to tread carefully in the products they offer and have been targeted for displaying sweets at the checkout, Smithââ¬â¢s has sold stationery aimed at teenagers and young women adorned with the Playboy bunny motif and Swannââ¬â¢s checkout assistants attempt to force-feed the nation giant bars of Galaxy and chocolate oranges. Her secret? Maybe itââ¬â¢s the low profile. While many rivals enjoy the limelight, holding forth on the woes of the economy, the lack of women in the boardroom and political issues such as the in-out debate, Swann says nothing. She doesnââ¬â¢t give interviews. On Wednesday, at Smithââ¬â¢s AGM, a shareholder stood to offer thanks for her transformation. Asked to respond, she merely said: ââ¬Å"Thank you, letââ¬â¢s move on. â⬠No doubt she will. There will be a queue for her services.
Thursday, August 15, 2019
It in video game industry Essay
Video Games were once a simple simulation of pong using two lines and a dot for imaging. They were played and mastered by a minority group of individuals most commonly referred to as ââ¬Å"nerdsâ⬠. Since those days in 1975 the video game industry market has gone through an exponential growth. With the revolutionary changes in technology and the social changes in product demand the gaming industry has transformed into a thriving market with a quickly growing casual gamer demographic. The success of this development in the gaming industry would be little without information technology. Information technology is a fundamental part of the gaming industry. Technology is used to handle information in the gaming industry in both the retail business side as well as the development aspect. When it comes to selling video games there used to only be the store but with the installment of new online technology, games for consumers have been easier to access. Companies like Gamefly enable users to buy and rent games online. Games also can even be instantly purchased over internet through gaming consoles. Microsoft is one company that has taken the most advantage of this concept. From personal experience using Microsoftââ¬â¢s console Xbox 360, the console offers users the ability to create an online account through Xbox Live. From the Xbox Live membership, users gain access to a wide online market of games, videos, and other additional products. The online market is extremely active with some games generating 100,000 trial downloads and 30,000 sales (Garcia, 2011). Despite the quick and easy access these technology features give to gamers the online world is also a threat to the security of games. Copyrights can be cracked, and sometimes games will be distributed over the internet to game users. The security risk the internet plays on games has been tackled by developers who believe cloud computing is the key. In 2009, video game developer Denis Dyack proposed during a panel discussion at GamesBeat that cloud computing would change the industry model of games depending on consoles to games depending on resources that only can be accessed over the internet (Bhanoo, 2009). By holding onto vital resources game developers can prevent the illegal distribution of their game content because the gameââ¬â¢s central assets are not downloaded. It would be a good model except one obstacle would be the probability that every game consumer has access to the internet which is highly unlikely, but it is growing to be common in today. These client-to-server concepts and ideas for the retail game industry would all be cases when information technology is used and needed. The gaming industry has a large amount to protect when it comes to distributing its product because unlike other products games are essentially data which is where the real information technology comes into play. The reason why video games are so vulnerable to piracy is because the data in them is not a physical entity but rather information that can be copied and released. Video games essentially can be viewed as an organized system of data and information technology which reacts to input from a user, simulating some type of an event. A look at one popular Massive Multiplayer Online (MMO) Game made by Blizzard known as World of Warcraft (WoW) can help demonstrate how complex these transfers of data and information are. Before the user can even begin playing they have to go through an entire sequence of account access authentication and communicate with a server to be verified of account access, and game access as well (Wilson). Once verified that the client computer is the account user and that account user has paid for the ability to the play the game the user selects the server there character is on or a server where they would like to make a new one (Wilson). 4 After character is selected the game play begins. All the data and information about the game graphics and environment are stored on the clientââ¬â¢s computer but the server is what does the communication of what gets to be displayed. A more detailed explanation would be the userââ¬â¢s character interacts with picking up an rock once the object is picked up the server communicates to the clientââ¬â¢s computer as well as other clients that the rock is no longer there (Wilson). 4 This client-to-server communication is simulated in many aspects of the game such as displaying other clients to the user and simulating a battle. When a client begins to fight with a creature the clients computer communicates both charactersââ¬â¢ stats to the server which then uses mathematic algorithms to calculate damage, healing, and any other real-time effects (Wilson). 4 This type of system requires a huge amount of backbone to perform. WoW is estimated to using about 20,000 computer systems and employs more than 4,600 people to keep its gaming experience running (Brice, 2009). While the server communication model used in WoW exhibits its simulation, it is not entirely the same for every video game. Not all games are like WoW, each one can vary with how it stores data and information. It really depends upon how game designers and programs architect the framework of their information technology systems. Systems like Blizzardââ¬â¢s are not on every game and that is because the programs designed to run the games are limited to the company (Wilson). 4 The program and framework of their information systems is the product of a company in the gaming industry and it is something that must be kept secret if the company wants to maintain business. Keeping secrets however, isnââ¬â¢t enough sometimes to stay in the business of the gaming industry. Other competitors can always challenge game developersââ¬â¢ business. The casual gamer is becoming the real market to making business in the gaming industry. There is still a high demand from the hardcore traditional gamer but when it comes to making video games, it is easy to agree it costs less to attract casual gamers with cheaper games. The app era with social networking sites and new technology such as the iPad is becoming a huge thorn to game developers, such as Nintendo president, Satoru Iwata, believing that cheap game apps are devaluing the industry (Morris, 2011). With game apps gamers no longer need to spend money as much money for entertainment unless they would like something with a little more depth. The rise of these game apps could be linked to the demand for cheaper products, especially when the economy is still trying to recover. Some developers argue back that the new app technology is not hindering the industry just changing it to a new way that expands the option to the casual gamer who only demands a simple game for entertainment (2010). It is not step back but instead a new branch to be explored and developed. Game apps do play some part in devaluing games but at least they have provided an opportunity for anxious developers to be involved in the game developing community. Either way itââ¬â¢s pursued game development is still a serious business which requires some serious skills with manipulating information. A deeper look into the development view of video games gives a better understanding of the how data and information technology relate to the industry. To understand the development process it is best to start looking at the model used to develop games. When broken down a game is really one big huge project broken down into many others. It starts with the Prototype, then Pre-Production, Production, Beta, and finally the Live finished product (Hendrick, 2009). Now with each of these projects the developers must initialize, plan, execute with monitoring and controlling, and then closing up and finishing (Hendrick, 2009). 8 These projects involve a variety of stages, from concept development to debugging. To be a part of this development process a game developer must be highly trained in whatever aspect they are adding to the project. A game programmer specifically must be able to meet a certain knowledge base criteria with computer languages, the most common one being C++. According to game programmer, Chad Stewart, it is essential that you ââ¬Å"Know Your Stuffâ⬠and understand how to think out loud with programming and create program models that can solve real-time problems and game mechanics (Stewart). When being interviewed he states that sometimes you will be presented with problem and must quickly illustrate on a white board how you would approach the problem (Stewart). 10 He also adds that it is important to not be discouraged if you fail the problem and show that you have a willingness to learn and it looks like there is plenty to catch up on (Stewart). 10 From the outside game development can look like a fun job but it is still a job that requires hard work. It can be nerve racking to imagine the amount of knowledge needed to be successful in the gaming industry. There is so much required to build and distribute a single game. That can especially be said for game programmers because they are required to update and learn new technologies. In the gaming industry it can be hard to find an expert that does it all, but one noticeable fact of life to remember is that people are always learning. Works Cited â⬠Programmer ââ¬â Computer Games ââ¬â Skillset. â⬠Welcome to Skillset ââ¬â Skillset.http://www. skillset. org/games/careers/profiles/article_4727_1. asp (accessed October 10, 2011). Bhanoo, Sindya . ââ¬Å"Cloud Computing May Curb Video Game Piracy CIO. com. â⬠CIO. com. http://www. cio. com/article/486979/Cloud_Computing_May_Curb_Video_Game_Piracy (accessed October 10, 2011). Brice, Katherine. ââ¬Å"Blizzard reveals full scale of World of Warcraft operation. â⬠GamesIndustry. biz. http://www. gamesindustry. biz/articles/blizzard-reveals-full-scale-of-world-of-warcraft-operation (accessed October 10, 2011). Garcia, Louis. ââ¬Å"Making money in Xbox 360 indie game development: Is it possible? | Bitmob. com. â⬠Bitmob. com. http://bitmob. com/articles/making-money-in-xbox-360-indie-game-development-is-it-possible (accessed October 10, 2011). Hendrick, Arnold. ââ¬Å"Project Management for Game Development à « MMO Tidbits. â⬠MMO Tidbits. http://mmotidbits. com/2009/06/15/project-management-for-game-development/ (accessed October 10, 2011). Morris, Chris. ââ¬Å"Are Apps Killing the Video Game Industry? ââ¬â CNBC. â⬠Stock Market News, Business News, Financial, Earnings, World Market News and Information ââ¬â CNBC. http://www. cnbc. com/id/41988262/Are_Apps_Killing_the_Video_Game_Industry (accessed October 10, 2011). Stewart, Chad. ââ¬Å"Chad Stewart Game Programmer.â⬠Chad Stewart Game Programmer. www. chadpluspl. us/? p=110 (accessed October 10, 2011). ââ¬Å"Video Game Industry 2010: Reinventing the Games Business. â⬠Game Industry News, Interviews and Videos | Game Theory. http://gametheoryonline. com/2010/07/28/video-games-industry-gaming-business/ (accessed October 10, 2011). ââ¬Å"Video Game Rentals: Rent/Buy Wii,PS3,PS2,Xbox,360,PSP,DS,3DS,GC,GBA Games. â⬠Gamefly. com. http://www. gamefly. com/ (accessed October 10, 2011). Wilson, Tracy V.. ââ¬Å"How World of Warcraft Works. â⬠HowStuffWorks ââ¬Å"Electronicsâ⬠. http://electronics. howstuffworks. com/world-of-warcraft6. htm (accessed October 10, 2011).
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