A Relationship Between Some Neurotransmitter Controlling...

Hypertension affects about 20 percent of the adult population placing a high burden on health care systems. CholinesterasesEC 3.1.1.7 and 3.1.1.8(ChEs)catalyze the neurotransmitteracetylcholine into choline and acetic acid, allowing a cholinergic neuron to return to resting state after activation. Monoamine oxidase E.C1.4.3.4 (MAO) is responsible for degradation of endogenous monoamine neurotransmitters and dietary amines. Nitric oxide(NO) is a gas produced in endothelial cells and platelets by endothelial NO synthase EC 1.14.13.39 (NOS). The aim of the present study is to find the relationship between some neurotransmitter-controlling enzymes and essential hypertension in recently diagnosed patients. Results†¦show more content†¦In classical essential hypertension both the systolic and diastolic blood pressures are high, but isolated systolic and isolated diastolic hypertension are also seen. Malignant or accelerated hypertension is associated with a rapid rise in arterial pressure and, if untreated, results in rapid end-organ damage and death(3). Obesity-related hypertension is an important public health issue. As the prevalence of obesity increases, the prevalence of hypertension with its associated CV risk will increase as well. (4) Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. MAO is the enzyme responsible for degradation of endogenous monoamine neurotransmitters and dietary amines, e.g. tyramine. Recently the cardiovascular field has focused on the role of MAO activity in the heart demonstrating the role of MAO-A as an important myocardial source of reactive oxygen species(ROS).(5) Depending on the concentrations of the available substrate, ROS produced by MAO-A are able to trigger separate signaling pathways leading respectively to cell proliferation and hypertrophy or apoptosis . Nitric oxide (NO) is a gas produced in endothelial cells and platelets by endothelial NO synthase (eNOS). This molecule maintains basal vasodilator tone, inhibits platelet aggregation,Show MoreRelatedControl And Essential Hypertension Patients1013 Words   |  5 Pagescontrol and essential hypertension patients. It has been found that the WBCs counts (7138 ±1444) and differential leukocytic percentage of neutrophils (60.385 ±9.014),eosinophils (6.86 ±1.573) and monocytes (7.154 ±1.519)of patients were higher than those of controls. Table 3 and figures 1-3indicate the values of measurements of true cholinesterase activity in units/l in male and female patients as well as control. It has been found that there is insignificant decrease between the mean ofRead MoreModule Quizzes Essay14245 Words   |  57 Pagesyour issue? â€Å"Have an issue† What days does this class meet? Never. It’s all on-line A student has missed 5 modules and asks Dr. Pozos to open those modules. The student has no excuse, but that she got caught up in the drama of life -the relationship broke up. The student reports this problem to Dr. Pozos 7 days after missing the 5th module. Dr. Pozos will? Not open them up due to the long time since the incident occurred What initially determines the value of the output? Controller WhichRead MoreSocm Study Guide Essay30404 Words   |  122 Pagesand movement. Refers to all chemical operations under way in the body. Define Anatomy and physiology, and describe the various specialties within each discipline Anatomy – the study of internal and external structures and the physical relationship between body parts. Physiology – the study of how living organisms p0erform the vital functions. Microscopic Anatomy – study of structures that can not be seen by the naked eye. Cytology – analyzes the internal structure of individual cells